First-in-Patient Unit

Research Environment in the Clinic

The First-in-Patient Unit (FiPU) of the LPI is a unique research environment within the clinic and serves as the central translational element of the LPI. It is a uniquely designed area of the Intensive Care Units at the Jena University Hospital (JUH) where patient rooms and laboratory units are spacially connected. Thus, the FiPU allows for testing of innovative diagnostic and therapeutic procedures under regulated clinical conditions at the bedside.

Within the LPI, rapid and accessible diagnostics, monitoring and therapeutic approaches for difficult-to-treat infections will be established. For the transfer of research results into the clinical application, and thus into patient care, methods and devices need to be clinically tested. This helps ensure that the applications deliver reliable, accurate outcomes and meet the intended clinical benefits for patients. At the FiPU at Jena University Hospital, innovative photonic diagnostic technologies and therapeutic treatment options can be tested, adapted and clinically validated under the highly regulated conditions of an Intensive Care Unit. The unique infrastructure, with patient beds located right next to the laboratories, thus enables the direct clinical application of new research concepts and methods. From 2027 onwards, pilot bedside studies will be launched at the FiPU.

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Direct lab access

Integrated laboratory unit for immediate sample processing and technology adaption

Special patient rooms

Located next to the labs for time-efficient treatment

Clinical expertise

Intensive care by highly qualified teams with wide experience in clinical studies

High safety

Regulated and safe environment for the clinical validations

 

Expanding Standard Diagnostics

At the FiPU, research and patient care will be joined – innovative diagnostics and treatment methods complement the conventional medicine. With this concept, the FiPU is unique in Germany. Due to precise intervention in the course of infection early-on, a full outbreak of infection can be hindered. Faster diagnoses and new therapy concepts can lead to higher patient health and shorter hospitalizations.

Photonic technologies like the RamanBioAssay™ provide new opportunities at the FiPU. The RamanBioAssay™ is a laser-based rapid test that enables the detection of bacteria and their antibiotic resistances within three hours. This ought to allow clinicians to adapt treatment strategies more rapidly.

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New Diagnostic Technologies and Future Therapeutic Approaches

Cutting-Edge Technology Approaches – as of 2027 

Multimodal spectroscopy (e.g. Raman microscopy) for rapid identification
of pathogens

Fiber optics-based technologies for
real-time monitoring of antibiotic effects

Non-invasive patient monitoring, e.g., via respiratory gas analysis
of volatile organic compounds

AI-supported analysis tools for automated, scalable and objective data evaluation

Therapeutic Perspectives

Nanoparticle-based substance release at the site of infection

Phage therapy to fight
multiresistant pathogens

Companion diagnostics for personalized therapies

The FiPU is funded by the Federal Ministry of Research, Technology and Space with over 6 million euros. With the start of the construction work at the JUH in spring of 2026, the FiPU marks the first phase of the centralization of the LPI infrastructure. The JUH is site owner of the executions.

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